STRUCTURE OF THYMIDYLATE KINASE REVEALS THE CAUSE BEHIND THE LIMITINGSTEP IN AZT ACTIVATION

Authors
LAVIE A VETTER IR KONRAD M GOODY RS REINSTEIN J SCHLICHTING I
Citation
A. Lavie et al., STRUCTURE OF THYMIDYLATE KINASE REVEALS THE CAUSE BEHIND THE LIMITINGSTEP IN AZT ACTIVATION, Nature structural biology, 4(8), 1997, pp. 601-604
Citations number
28
Categorie Soggetti
Biology,"Cell Biology
Journal title
Nature structural biology → ACNP
ISSN journal
10728368
Volume
4
Issue
8
Year of publication
1997
Pages
601 - 604
Database
ISI
SICI code
1072-8368(1997)4:8<601:SOTKRT>2.0.ZU;2-X
Abstract
Structural comparison of thymidylate kinase complexed with either dTMP or with AZTMP suggests that the low phosphorylation rate of AZTMP is due to an induced P-loop movement.