Factors affecting renal function in 119,985 adults over three years

Blood pressure, proteinuria and serum creatinine (SCr) were examined in 119 985 adults, aged 40 years and older, who attended annual health examination s both in 1993 and 3 years later. Renal function was assessed from SO; chan ges in individuals' renal function were estimated using the slope of the re gression line for the reciprocal of the SCr level vs. time (slope of rSCr) over the 3-year period. Age-dependent SO concentration increments were obse rved; however, there was no significant age-dependent change in the slope o f rSCr. SCr in hypertensives on anti-hypertensive medication was significan tly higher than that in untreated hypertensives, borderline hypertensives a nd normotensives. The slopes of rSCr in hypertensives (treated, untreated a nd borderline) were steeper than normotensives in males, and that in untrea ted hypertensives was steeper than other groups in females. In hypertensive s with proteinuria, SCr was higher and renal function deteriorated more rap idly, compared with hypertensives without proteinuria. Hypertension with pr oteinuria appears to be an important indicator for progressive decline in r enal function, this trend being more obvious in males. Renal function decre ases with age; however, the rate of decline is constant. The influences of proteinuria and blood pressure on renal function are different in males and females.