Indications and results of liver resection and hepatic chemoembolization for metastatic gastrointestinal neuroendocrine tumors

Background. We reviewed 36 patients with liver metastases from islet cell t umors of the pancreas (n = 18) and carcinoid tumors (n = 18) who were treat ed with surgical resection (n = 16) or hepatic chemoembolization (n = 20). Methods. All resections were complete and included 4 lobectomies, 6 segment al resections, and 6 wedge resections. There were no operative deaths. Results. Median survival has not yet been reached, and the actuarial 5-year survival rate is 70%. Prognostic variables associated with improved diseas e-free survival included prior resection of the primary tit mor and 4 or fe wer metastases resected, (P < .05). With an average of 3 chemoembolization procedures per patient, 17 of 20 patients (90%) demonstrated either a signi ficant radiographic response (n = 5), stabilization of tumor mass (n = 2), or improvement of clinical symptoms (n = 10). Factors related to a sustaine d response (more then 1 year) included surgical resection of the primary tu mor, 4 or more chemoembolization procedures, and liver metastases of 5 cm o r smaller. Median survival after treatment was 32 months (range, 7-63 month s), and the actuarial 5-year survival rate was 40%. Conclusions. Surgical resection of metastatic neuroendocrine tumors provide s the best chance for extended survival. Chemoembolization effectively impr oves clinical symptoms and, in selected patients, may provide sustained tum or control.