Parallel synthesis of dihydropyrimidinones using Yb(III)-resin and polymer-supported scavengers under solvent-free conditions. A green chemistry approach to the Biginelli reaction

Authors
Dondoni, A Massi, A
Citation
A. Dondoni et A. Massi, Parallel synthesis of dihydropyrimidinones using Yb(III)-resin and polymer-supported scavengers under solvent-free conditions. A green chemistry approach to the Biginelli reaction, TETRAHEDR L, 42(45), 2001, pp. 7975-7978
Citations number
27
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
45
Year of publication
2001
Pages
7975 - 7978
Database
ISI
SICI code
0040-4039(20011105)42:45<7975:PSODUY>2.0.ZU;2-J
Abstract
An efficient synthesis of an array of 3,4-dihydropyrimidin-2-(1H)-ones usin g solid-supported ytterbium(III) reagent from aldehydes, 1,3-dicarbonyl com pounds and urea (Biginelli reaction) under solvent-free conditions is descr ibed. Purification of each member of the library was carried out using a co cktail of acid and basic polymer-supported scavengers (C) 2001 Elsevier Sci ence Ltd. All rights reserved.