Use of a racemic derivatizing agent for measurement of enantiomeric excessby circular dichroism spectroscopy

Authors
Hattori, T Minato, Y Yao, SL Finn, MG Miyano, S
Citation
T. Hattori et al., Use of a racemic derivatizing agent for measurement of enantiomeric excessby circular dichroism spectroscopy, TETRAHEDR L, 42(45), 2001, pp. 8015-8018
Citations number
23
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
45
Year of publication
2001
Pages
8015 - 8018
Database
ISI
SICI code
0040-4039(20011105)42:45<8015:UOARDA>2.0.ZU;2-0
Abstract
Enantiomeric excesses of several alcohols and an amine have been determined by derivatization with racemic 2'-methoxy-1,1'-binaphthyl-2-carbonyl chlor ide rac-1, with no requirement for kinetic resolution in the acylation step . The necessary information is provided instead by CD and UV spectra of the derived esters and amides, the chiral signal being dominated by the binaph thyl component. (C) 2001 Elsevier Science Ltd. All rights reserved.