The influence of imine structure, catalyst structure and reaction conditions on the enantioselectivity of the alkylation of alanine methyl ester imines catalyzed by Cu(ch-salen)
Yn. Belokon' et al., The influence of imine structure, catalyst structure and reaction conditions on the enantioselectivity of the alkylation of alanine methyl ester imines catalyzed by Cu(ch-salen), TETRAHEDR L, 42(45), 2001, pp. 8093-8096
Systematic variation of the substrate structure has shown that the most eff
ective substrates for Cu(ch-salen)-catalyzed asymmetric enolate alkylation
reactions carried out under phase-transfer conditions are the para-chloroph
enyl imines of amino esters. The other reaction parameters (solvent and sti
rring speed) have also been optimized. The introduction of substituents ont
o the aryl rings of the salen ligand was found not to have a beneficial eff
ect on the enantioselectivity of the reaction. (C) 2001 Elsevier Science Lt
d. All rights reserved.