Enantioselective copper-catalyzed conjugate addition using chiral diaminocarbene ligands

Authors
Guillen, F Winn, CL Alexakis, A
Citation
F. Guillen et al., Enantioselective copper-catalyzed conjugate addition using chiral diaminocarbene ligands, TETRAHEDR-A, 12(15), 2001, pp. 2083-2086
Citations number
28
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
12
Issue
15
Year of publication
2001
Pages
2083 - 2086
Database
ISI
SICI code
0957-4166(20010829)12:15<2083:ECCAUC>2.0.ZU;2-#
Abstract
Chiral diaminocarbene ligands, generated by in-situ deprotonation of the co rresponding chiral imidazolinium salts, are shown to be efficient ligands i n the asymmetric copper-catalyzed 1,4-conjugate addition of diethylzinc to enones, allowing enantiomeric excesses of up to 51% to be achieved. (C) 200 1 Elsevier Science Ltd. All rights reserved.