Synthesis of (-)-(1 ' S,4aS,8aR)- and (+)-(1 ' S,4aR,8aS)-4a-ethyl-1-(1 '-phenylethyl)-octahydroquinolin-7-ones

Authors
Vazquez, E Galindo, A Gnecco, D Bernes, S
Citation
E. Vazquez et al., Synthesis of (-)-(1 ' S,4aS,8aR)- and (+)-(1 ' S,4aR,8aS)-4a-ethyl-1-(1 '-phenylethyl)-octahydroquinolin-7-ones, TETRAHEDR-A, 12(15), 2001, pp. 2099-2102
Citations number
14
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
12
Issue
15
Year of publication
2001
Pages
2099 - 2102
Database
ISI
SICI code
0957-4166(20010829)12:15<2099:SO('SA>2.0.ZU;2-S
Abstract
A synthesis of the enamine (-)-(1'S)-5-ethyl-1-(1'-phenylethyl)-1,2,3,4-tet rahydropyridine 4 and its application in a synthesis of (-)-(1'S,4aS,8aR)- and (+)-(1'S,4aR,8aS)-4a-ethyl-1-(1'-phenylethyl)-octahydroquinolin-7-ones 5 and 6 is described. In addition, an X-ray study of 6 is reported. Finally , the preparation of (4aS,8aR)-4a-ethyl-octahydroquinolin-7-one 7 is descri bed. (C) 2001 Elsevier Science Ltd. All rights reserved.