Preliminary characteristics of the prothrombin converting enzyme from venom of Stephen's banded snake (Hoplocephalus stephensii)

Authors
Weinstein, SA Williams, V White, J
Citation
Sa. Weinstein et al., Preliminary characteristics of the prothrombin converting enzyme from venom of Stephen's banded snake (Hoplocephalus stephensii), TOXICON, 39(12), 2001, pp. 1937-1939
Citations number
15
Categorie Soggetti
Pharmacology & Toxicology
Journal title
TOXICON
ISSN journal
00410101 → ACNP
Volume
39
Issue
12
Year of publication
2001
Pages
1937 - 1939
Database
ISI
SICI code
0041-0101(200112)39:12<1937:PCOTPC>2.0.ZU;2-F
Abstract
Stephen's banded snake (Hoplocephalus stephensii) is an infrequently encoun tered Australian elapid species. The crude venom contains coagulant activit y and the component responsible is a prothrombin activator requiring factor V for activity. SDS-PAGE of the isolated native protein revealed two bands at 23 and 36 kDa. These findings indicate that the procoagulant is similar to that found in the Australian tiger snake (Notechis scutatus) and thus r esembles factor Xa. (C) 2001 Elsevier Science Ltd. All rights reserved.