The interplay between Mad and Myc in proliferation and differentiation

Authors
Zhou, ZQ Hurlin, PJ
Citation
Zq. Zhou et Pj. Hurlin, The interplay between Mad and Myc in proliferation and differentiation, TR CELL BIO, 11(11), 2001, pp. S10-S14
Citations number
30
Categorie Soggetti
Cell & Developmental Biology
Journal title
TRENDS IN CELL BIOLOGY
ISSN journal
09628924 → ACNP
Volume
11
Issue
11
Year of publication
2001
Pages
S10 - S14
Database
ISI
SICI code
0962-8924(200111)11:11<S10:TIBMAM>2.0.ZU;2-Y
Abstract
Members of the Myc family of transcription factors are key regulators of ce ll proliferation, and excessive levels of Myc lead to tumor formation. Mad family proteins are related to Myc, but they antagonize the oncogenic activ ity of Myc in cell-culture assays. Here, we examine current models of Mad f unction and the relationship between Mad and Myc in cell proliferation, dif ferentiation and tumorigenesis.