Glutathione is one of the major redox buffers in most aerobic cells, and it
has a broad spectrum of functions in plants. Recent discoveries implicate
this thiol peptide in signalling and cellular homeostasis. Glutathione can
sense intracellular redox status: perturbations of glutathione reduction st
ate are transduced into changes in gene expression. This central role deman
ds precise control of both the concentration and the reduction state of glu
tathione in different compartments. In addition to the regulation of glutat
hione biosynthesis and redox state, attention is now turning to the role of
glutathione transporters.