The goal of immunomodulation in food-producing animals is to regulate immun
ity for the benefit of the animal and production efficiency. Immunomodulato
rs are substances that exert this control and include cytokines, pharmaceut
icals, microbial products, nutraceuticals, and traditional medicinal plants
. Although treatment and prevention of infectious diseases are the most com
mon reasons to use immunomodulators, other conditions, such as amelioration
of stress-induced immunosuppression, maturation of the neonate's developin
g immune response, and strategies to reduce the metabolic cost of eliciting
an immune response also are well suited for immunomodulation. Continued di
scovery of new immune regulators and increased understanding of immunity in
food-producing animals will ensure new opportunities for the use of immuno
modulators in food-producing animals.