Effects,of extract F of red-rooted Salvia on mucosal lesions of gastric corpus and antrum induced by hemorrhagic shock-reperfusion in rats

AIM To compare the effects of extract F of red-rooted Salvia (EFRRS) on muc osal lesions of gastric corpus and antrum induced by hemorrhagic shock and reperfusion in rats. METHODS The rats were subject to hemorrhagic shock and followed by reperfus ion, and were divided randomly into two groups. Group I received saline, an d group 2 received EFRRS intravenously. The index of gastric mucosal lesion s (IGML) was expressed as the percentage of lesional area in the corpus or antrum. The degree of gastric mucosal lesions (DGML) was catalogued grade 0 , 1, 2 and 3. The concentrations of prostaglandins (PGs) were measured by r adioimmunoassay. The concentration of MDA was measured according to the pro cedures of Asakawa. The activity of SOD was measured by the biochemical way . The growth rates or inhibitory rates of above-mentioned parametes were ca lculated. RESULTS As compared with IGML (%), grade 3 damage (%) and MDA content (nmol / g tissue) of gastric antrum which were respectively 7.96 +/- 0.59, 34.86 +/- 4.96 and 156.98 +/- 16.12, those of gastric corpus which were respectiv ely 23.18 +/- 6.82, 58.44 +/- 9.07 and 230.56 +/- 19.37 increased markedly (P <0.01), whereas the grade 0 damage, grade I damage, the concentrations o f PGE(2) and PGl(2)(pg/ mg tissue), the ratio of PGl(2)/ TXA(2) and the act ivity of SOD ( U/ g tissue) of corpus which were respectively 3.01 +/- 1.01 , 8.35 +/- 1.95, 540.48 +/- 182.78, 714.38 +/- 123,74, 17.38 +/- 5.93 and 1 34.29 +/- 13.35 were markedly lower than those of antrum which were respect ively 13.92 +/- 2.25, 26.78 +/- 6.06, 2218.56 +/- 433.12, 2531.76 +/- 492.3 5, 43.46 +/- 8.51 and 187.45 +/- 17.67 (P<0.01) after hemorrhagic shock and reperfusion. After intravenous EFRRS, the growth rates (%) of grade 0 dama ge, grade I damage, the concentrations of PGE, and PGl(2), the ratio of PGl (2)/ TXA2 and the activity of SOD of corpus which were respectively 632.56, 308.62, 40.75, 74.75, 92.29 and 122.25 were higher than those in antrum wh ich were respectively 104.89, 58.40, 11.12, 56.58, 30.65 and 82.64, whereas the inhibitory rates (%) of IGML, grade 3 damage and MDA content of gastri c corpus were 82.93, 65.32 and 59.09, being higher than those of gastric an trum which were 76.64, 53.18 and 42.37. CONCLUSION After hemorrhagic shock-reperfusion, the gastric mucosal lesions in the corpus were more severe than those in the antrum, which were relate d not only to the different distribution of endogenous PGs in the mucosa, b ut also to the different ability of anti-oxidation of the mucosa. The prote ctive effect of EFRRS on the gastric mucosa in the corpus was more evident than that in the antrum, which was related to higher growth degree of PGs c ontents and anti-oxitative ability in gastric corpus after administration o f EFRRS.