Although diagnostic imaging is now highly developed, neural blockade provid
es another opportunity to test for a source of pain that may frequently lea
ve no signature. Likewise, many neuropathic pains can not be tested by neur
odiagnostic methods. This paper makes a case for the continued use of regio
nal anesthesia to assist in the diagnosis and therapy of chronic pain. In p
articular, the example of autonomic blocks and blocks of the axial spine ar
e emphasized. Nerve blocks require an understanding of the anatomy, physiol
ogy, pharmacology, and the ability to interpret critically their results.