Citation
Y. Wu et Jc. Xu, Synthesis of chiral phosphono-peptide nucleic acid monomers, ACT CHIM S, 59(10), 2001, pp. 1660-1666
Citations number
29
Categorie Soggetti
Chemistry
Journal title
ACTA CHIMICA SINICA
ISSN journal
05677351
→ ACNP
Volume
59
Issue
10
Year of publication
2001
Pages
1660 - 1666
Database
ISI
SICI code
0567-7351(2001)59:10<1660:SOCPNA>2.0.ZU;2-H
Abstract
Peptide nucleic acids are the potential candidate of antisense and anitgene
. Chiral monomer backbones were efficiently prepared by reductive amination
of N - Boc or N - Fmoc protected L alaninal with aminomethylphosphate diet
hyl ester and subsequent acylation of free secondary amines with thymine -
1 - ylacetic acid. After chemical switch of N - Boc to N - Fmoc, protected
chiral phosphono - PNA monomers were obtained.