Molecular diversity of Tonghaosu analogs synthesis of 2-(Z)-benzylidene-1,6,9-trioxaspiro[4,5]dec-3-ene

By using the dehydration - spiroketalization of corresponding furanyldiols discovered in our laboratory as the key reaction to construct the trioxaspi ro [4, 5] dec - 3 - ene nucleus, we have developed a practical synthetic ro ute to Tonghaosu analogs, a class of compounds characterized by a unique sp iroketal enol ether motif, and thus created an expeditious access to the mo lecular diversity of this type of substances that already show interesting activities in preliminary biological tests.