Fat tissue is abundant in the body and preferred in soft tissue augmentatio
n. Since resorption is its greatest disadvantage, many agents have been tri
ed in an attempt to increase fat graft survival in various studies. Yet sel
ective beta1 blocker had not been used before. The effect of selective beta
1 blockers on resorption following auto-transplantation of free fat graft w
as examined in rats. The effect of selective beta1 blockers was compared wi
th those of insulin and saline solution as a control. For this comparison,
the weight of fat grafts was measured both during and nine months after ope
ration using the "liquid overflow method" in which obtained material was pu
t into 5 cc syringe filled with saline solution and the increase in liquid
level was recorded as graft volume. Histological examination of grafts and
statistical analyses of the results were also made. Our in vivo study demon
strated that selective beta1 blocker significantly increased free fat graft
survival. It is our conclusion that selective beta1 blocker is a promising
agent for decreasing fat graft resorption.