Keratitis caused by Candida glabrata in a patient with chronic granulomatous disease

PURPOSE: To report an unusual ocular presentation of Candida glabrata in a patient with chronic granulomatous disease. METHODS: Interventional case report. A 15-year-old boy with chronic granulo matous disease presented with bilateral limbal infiltrates. He had been rec eiving broad-spectrum systemic antibiotics for recurrent liver abscesses. T he keratitis did not respond to antibiotics and did not resolve after a cou rse of topical steroids. RESULTS: Corneal cultures revealed Candida glabrata. The same species was s imultaneously isolated from the surgical drainage of the liver abscesses. T he ocular and hepatic findings resolved on intravenous amphotericin B. CONCLUSION: Candida glabrata has recently emerged as an important nosocomia l pathogen. It may present as a limbal keratitis in the setting of systemic infection. (C) 2001 by Elsevier Science Inc. All rights reserved.