Case-control study of the extended tau gene haplotype in Parkinson's disease

We investigated the association of Parkinson's disease with tau gene haplot ypes. In a sample of 319 unrelated Parkinson's disease patients and 196 con trol subjects, we observed an increased risk of Parkinson's disease for per sons with the H1/H1 genotype (odds ratio = 1.5; 95% confidence interval: 0. 98-2.23); however, the finding was not statistically significant. The resul ts remained similar after adjusting for the possible misclassification of p rogressive supranuclear palsy patients as Parkinson's disease, but became s tatistically significant after restricting the analysis to nondemented subj ects.