This article examines the development of anthropological research in respon
se to AIDS. During the first decade of the epidemic, most social science re
search focused on the behavioral correlates of HIV infection among individu
als and failed to examine broader social and cultural factors. By the late
1980s, however, pioneering work by anthropologists began to raise the impor
tance of cultural systems in shaping sexual practices relevant to HIV trans
mission and prevention. Since the start of the 1990s, this emphasis on cult
ural analysis has taken shape alongside a growing anthropological research
focus on structural factors shaping vulnerability to HIV infection. Work on
social inequality and the political economy of HIV and AIDS has been espec
ially important. Much current research seeks to integrate both cultural and
structural concerns in providing an alternative to more individualistic be
havioral research paradigms.