Extended follow-up of anti-HBe-positive chronic hepatitis B retreated withribavirin patients with and interferon-alpha

In a pilot study of combination therapy with ribavirin and IFN alpha conduc ted in anti-HBe-positive individuals with chronic hepatitis B, 21% of patie nts achieved a sustained ALT normalization and clearance of hepatitis B vir us (HBV) DNA as measured by PCR. The present work has assessed whether thes e sustained responses are lasting long-term. In addition, IFN gamma levels were tested serially in serum as a measure of the immune system activation during treatment. By extending the post-treatment follow-up period 2 years the occurrence of delayed HBV DNA relapses was observed. A low serum level of IFN gamma was detected during and after treatment. IFN gamma demonstrate d a multiphasic time-course: the amount of IFN gamma increased in parallel with reductions in HBV DNA but also with ALT flare-ups. In conclusion, the extended follow-up study of anti-HBe-positive patients after combined treat ment with ribavirin and IFN alpha has shown that sustained responses are la sting in 17% patients but also that a late onset HBV DNA relapse may occur. (C) 2001 Published by Elsevier Science B.V.