Interaction between methotrexate and ciprofloxacin: report of two cases ofsevere intoxication

Methotrexate elimination may be delayed by different drugs. Such a delay ma y produce severe toxic complications. Case reports. - We report two cases of adolescents treated for malignant di seases who presented a delayed methotrexate elimination even though they re ceived ciprofloxacin. The first patient had already received several course s of methotrexate without toxicity before this episode. The second patient tolerated methotrexate when ciprofloxacin was not associated to the treatme nt. Conclusion. - High-dose methotrexate-ciprofloxacin association should be av oided. (C) 2001 Editions scientiliques et medicales Elsevier SAS.