Selenazolidines as novel organoselenium delivery agents

Authors
Xie, Y Short, MD Cassidy, PB Roberts, JC
Citation
Y. Xie et al., Selenazolidines as novel organoselenium delivery agents, BIOORG MED, 11(22), 2001, pp. 2911-2915
Citations number
27
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
22
Year of publication
2001
Pages
2911 - 2915
Database
ISI
SICI code
0960-894X(20011119)11:22<2911:SANODA>2.0.ZU;2-L
Abstract
Two new classes of selenazolidine-4(R)-carboxylic acids (2-oxo and 2-methyl -SCAs) were synthesized and characterized. Both were designed as latent for ms of selenocysteine, intended to provide a chemically superior delivery fo rm for selenium. The prodrugs may be clinically useful when selenium supple mentation at supranutritional levels is indicated, such as in cancer chemop revention. (C) 2001 Elsevier Science Ltd. All rights reserved.