Enols as potent antibacterial agents

Authors
Thorarensen, A Zurenko, GE Sweeney, MT Marotti, KR Boyle, TP
Citation
A. Thorarensen et al., Enols as potent antibacterial agents, BIOORG MED, 11(22), 2001, pp. 2931-2934
Citations number
11
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
22
Year of publication
2001
Pages
2931 - 2934
Database
ISI
SICI code
0960-894X(20011119)11:22<2931:EAPAA>2.0.ZU;2-V
Abstract
This paper describes the discovery of alpha -trifluoroketoacetamides as pot ent antibacterial agents against Gram-positive organisms. The initial SAR i ndicates that the aryl ethyl side chain is essential in maintaining antibac terial activity. The SAR observations have been utilized to design a bioiso stere for the alpha -trifluoroketoacetamide with good activity against Gram -positive organisms. (C) 2001 Elsevier Science Ltd. All rights reserved.