Design, synthesis, and SAR of amino acid derivatives as factor Xa inhibitors

Authors
Su, T Wu, YH Doughan, B Jia, ZJ Woolfrey, J Huang, B Wong, P Park, G Sinha, U Scarborough, RM Zhu, BY
Citation
T. Su et al., Design, synthesis, and SAR of amino acid derivatives as factor Xa inhibitors, BIOORG MED, 11(22), 2001, pp. 2947-2950
Citations number
17
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
22
Year of publication
2001
Pages
2947 - 2950
Database
ISI
SICI code
0960-894X(20011119)11:22<2947:DSASOA>2.0.ZU;2-V
Abstract
A series of potent and selective factor Xa inhibitors was synthesized using various readily available amino acids as central templates. The most poten t compound displays IC50 of 3 nM. (C) 2001 Elsevier Science Ltd. All rights reserved.