3-aryl-4-aryloyl-1-(1H-imidazol-5-yl)methylpyrrole, a novel class of farnesyltransferase inhibitors

Authors
Lee, H Lee, J Shin, Y Jung, W Kim, JH Park, K Ro, S Chung, HH Koh, JS
Citation
H. Lee et al., 3-aryl-4-aryloyl-1-(1H-imidazol-5-yl)methylpyrrole, a novel class of farnesyltransferase inhibitors, BIOORG MED, 11(22), 2001, pp. 2963-2965
Citations number
21
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
22
Year of publication
2001
Pages
2963 - 2965
Database
ISI
SICI code
0960-894X(20011119)11:22<2963:3ANCOF>2.0.ZU;2-2
Abstract
Design, synthesis and structure-activity relationship of a class of 3-aryl- 4-aryloyl-1-(1H-imidazol-5-yl)methylpyrroles asl farnesyltransferase inhibi tors are described. Compound 7 inhibits farnesyltransferase with an IC50 va lue of 4.6 nM. (C) 2001 Elsevier Science Ltd. All rights reserved.