The discovery of anthranilic acid-based MMP inhibitors. Part 3: Incorporation of basic amines

Authors
Levin, JI Chen, JM Du, MT Nelson, FC Wehr, T DiJoseph, JF Killar, LM Skala, S Sung, A Sharr, MA Roth, CE Jin, G Cowling, R Di, L Sherman, M Xu, ZB March, CJ Mohler, KM Black, RA Skotnicki, JS
Citation
Ji. Levin et al., The discovery of anthranilic acid-based MMP inhibitors. Part 3: Incorporation of basic amines, BIOORG MED, 11(22), 2001, pp. 2975-2978
Citations number
17
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
22
Year of publication
2001
Pages
2975 - 2978
Database
ISI
SICI code
0960-894X(20011119)11:22<2975:TDOAAM>2.0.ZU;2-Y
Abstract
Anthranilic acid derivatives bearing basic amines were prepared and evaluat ed in vitro and in vivo as inhibitors of MMP-1, MMP-9, MMP-13, and TACE. Pi perazine 4u has been identified as a potent, selective, orally active inhib itor of MMP-9 and MMP-13. (C) 2001 Elsevier Science Ltd. All rights reserve d.