Novel synthesis and RNA-binding properties of aminoglycoside dimers conjugated via a naphthalene diimide-based intercalator

Authors
Tok, JBH Fenker, J
Citation
Jbh. Tok et J. Fenker, Novel synthesis and RNA-binding properties of aminoglycoside dimers conjugated via a naphthalene diimide-based intercalator, BIOORG MED, 11(22), 2001, pp. 2987-2991
Citations number
28
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
22
Year of publication
2001
Pages
2987 - 2991
Database
ISI
SICI code
0960-894X(20011119)11:22<2987:NSARPO>2.0.ZU;2-6
Abstract
The synthesis and RNA-binding properties of naphthalene-based diimide conju gated bis-aminoglycoside antibiotics are reported. Compared to the monomeri c aminoglycoside, the conjugated ligands were observed to attain up to 35-f old enhancement in binding affinity towards a novel RNA construct that cont ained two 16S rRNA A-sites. (C) 2001 Elsevier Science Ltd. All rights reser ved.