Antibacterial agents that inhibit histidine protein kinase YycG of Bacillus subtilis

Authors
Yamamoto, K Kitayama, T Minagawa, S Watanabe, T Sawada, S Okamoto, T Utsumi, R
Citation
K. Yamamoto et al., Antibacterial agents that inhibit histidine protein kinase YycG of Bacillus subtilis, BIOS BIOT B, 65(10), 2001, pp. 2306-2310
Citations number
22
Categorie Soggetti
Agricultural Chemistry","Biochemistry & Biophysics
Journal title
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
ISSN journal
09168451 → ACNP
Volume
65
Issue
10
Year of publication
2001
Pages
2306 - 2310
Database
ISI
SICI code
0916-8451(200110)65:10<2306:AATIHP>2.0.ZU;2-9
Abstract
We demonstrated in vitro that YycG-YycF of Bacillus subtilis constitutes a two-component system and shows a specificity of the sensor protein for the cognate phosphorylation partner. Based on inhibition of such an autophospho rylation of YycG, we searched imidazole and zerumbone derivatives to identi fy the antibacterial agents such as NH125, NH126, NH127, and NH0891.