Citation
K. Nakahara et al., Antimutagenic activity against Trp-P-1 of the edible Thai plant, Oroxylum indicum Vent., BIOS BIOT B, 65(10), 2001, pp. 2358-2360
Citations number
17
Categorie Soggetti
Agricultural Chemistry","Biochemistry & Biophysics
Journal title
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
ISSN journal
09168451
→ ACNP
Volume
65
Issue
10
Year of publication
2001
Pages
2358 - 2360
Database
ISI
SICI code
0916-8451(200110)65:10<2358:AAATOT>2.0.ZU;2-X
Abstract
A methanolic extract of Oroxylum indicum strongly inhibited the mutagenicit
y of Trp-P-1 in an Ames test. The major antimutagenic constituent was ident
ified as baicalein with an IC50 value of 2.78 +/- 0.15 muM. The potent anti
mutagenicity of the extract was correlated with the high content (3.95 +/-
0.43%, dry weight) of baicalein. Baicalein acted as a desmutagen since it i
nhibited the N-hydroxylation of Trp-P-2.