Deterioration of axotomy-induced neurodegeneration by group IIA secretory phospholipase A(2)

Authors
Yagami, T Ueda, K Asakura, K Hori, Y
Citation
T. Yagami et al., Deterioration of axotomy-induced neurodegeneration by group IIA secretory phospholipase A(2), BRAIN RES, 917(2), 2001, pp. 230-234
Citations number
22
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
00068993 → ACNP
Volume
917
Issue
2
Year of publication
2001
Pages
230 - 234
Database
ISI
SICI code
0006-8993(20011102)917:2<230:DOANBG>2.0.ZU;2-#
Abstract
Phospholipase A(2) (PLA(2)) is proposed to play a role in the repair of the ruptured membrane after axotomy. In neonatal rats, we examined the effect of Group IIA secretory PLA(2) (sPLA(2)-IIA) on axotomy-induced cell death o f motoneurons. sPLA(2)-IIA significantly induced death of axotomized motone urons. Indoxam, a specific inhibitor for sPLA(2)-IIA, protected motoneurons from the sPLA(2)-IIA-induced deterioration. The present study indicated th at sPLA(2)-IIA possessed neurotoxic effect rather than neuroprotective effe ct against facial nerve. (C) 2001 Elsevier Science B.V. All rights reserved .