Inhibitory effect of flavonoid derivatives on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumors

Authors
Iwase, Y Takemura, Y Ju-ichi, M Mukainaka, T Ichiishi, E Ito, C Furukawa, H Yano, M Tokuda, H Nishino, H
Citation
Y. Iwase et al., Inhibitory effect of flavonoid derivatives on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumors, CANCER LETT, 173(2), 2001, pp. 105-109
Citations number
9
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER LETTERS
ISSN journal
03043835 → ACNP
Volume
173
Issue
2
Year of publication
2001
Pages
105 - 109
Database
ISI
SICI code
0304-3835(20011128)173:2<105:IEOFDO>2.0.ZU;2-2
Abstract
To search for possible anti-tumor promoters, ten flavonoid derivatives (1-1 0) synthesized from morin and quercetin were examined for their inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation by a sh ort-term in vitro assay. Of these compounds, pentaallyl ethers (9, 10) show ed significant inhibitory effects on EBV-EA activation induced by the tumor promoter, 12-O-tetradecanoylphorbol 13-acetate. Further, quercetin pentaal lyl ether (10) exhibited remarkable inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. (C) 2001 Elsevier Sc ience Ireland Ltd. All rights reserved.