A new quantitative parameter, diffuse index (DI), was proposed to evaluate
objectively whether in-stent restenosis is diffuse or focal in nature. A to
tal of 343 patients (346 lesions) with Wiktor-GX, AVE MS-II, or JOMED stent
s were evaluated at follow-up angiography. According to the OCA-CMS definit
ion, lesion length is derived from the 100% reference diameter function (RD
F). By moving the RDF downward, the lesion length, LL(x), at each percentag
e x of the RDF can be calculated. We have defined the DI by the ratio of th
is calculated length LL(x) and the total stent length, SL, in other words,
DI = [LL(x)/SL]. The percentage plaque area (% PA) was calculated by dividi
ng the plaque area by the sum of the plaque area and luminal area within th
e stent. An excellent correlation was found between the DI at 88% RDF and t
he % PA in all three stents (r > 0.88). The individual correlation curves w
ere nearly identical, independent of the type of stent. Furthermore, based
on the overall data, the combination of a DI > 0.8 and % PA > 30% correlate
d with a high incidence of subsequent major adverse cardiac events (13/25 =
52%). From these data, it can be concluded that the diffuse index is a new
objective quantitative parameter to describe whether in-stent restenosis i
s of focal or diffuse nature. (C) 2001 Wiley-Liss, Inc.