In vitro study of FFR, QCA, and IVUS for the assessment of optimal stent deployment

We tested whether fractional flow reserve (FFR) discriminates between subop timally and optimally deployed stents. Latex tubes (diameter circle divide = 4 mm) with diameter stenosis 40% (n = 3), 50% (n = 3) and 60% (n = 3) wer e tested in a pulsatile flow system, using water. Measurements were done at baseline (n = 9; FFR/QCA) and after suboptimal (SOD; 3-mm balloon at 8 atm ) and optimal (OD; 4 mm balloon at 16 atm) deployment of a 35-mm stent (n = 6; FFR/OCA/IVUS). Varying Q from 150 to 50 ml/min increased FFR by 2-7%. C onversely, at 100 ml/min, FFR increased by only 0.8% from SOD to OD (P < 0. 05). Extrapolating data to blood flow, the gain in FFR from SOD to OD is le ss than 5% for Q = 100 ml/min, while FFR may increase by 15-20% by changes in blood flow from 50 to 150 ml/min. We conclude that IVUS and OCA are more appropriate for the assessment of optimal stent deployment. (C) 2001 Wiley -Liss, Inc.