Potential triggering factors of intracerebral hemorrhage

The distributions of intracerebral hemorrhage (ICH) according to place of o nset, degree of physical activity at onset and potential triggering factors were analyzed in 848 patients with ICH. Patients were grouped according to the presumed cause of ICH: hypertensive ICH, secondary ICH and ICH of unde termined origin. The influence of demographic and temporal factors on the r elative frequency of events was also assessed. In 30% of the cases, ICH occ urred during inactivity or sedentary activity, in 50% during light exertion and in 20% during moderate/ vigorous exertion. During inactivity or sedent ary activity, hypertensive ICH was significantly less frequent than seconda ry ICH (OR 0.32; 95% Cl 0.21-0.47) and undetermined ICH (OR 0.36; 95% Cl 0. 23-0.55), whereas during moderate or vigorous exertion hypertensive ICH was more frequent than secondary (OR 1.88; 95% Cl 1.16-3.05) and undetermined ICH (OR 2.29; 95% Cl 1.31-4.00) Potential triggering factors were observed in 27% of patients and were significantly more frequent in patients with hy pertensive ICH than in patients with secondary ICH (OR 2.90; 95% Cl 1.85-4. 54) or undetermined ICH (OR 2.44; 95% Cl 1.54-3.87). Our findings suggest t hat many potential external triggers that act mainly by raising blood press ure may interact, and their concurrence may favor cerebral hemorrhage, part icularly in hypertensive patients. In many cases, these circumstances of in creased risk may be mitigated by preventive measures. Copyright (C) 2001 S. Karger AG, Basel.