Behcet's disease: An update on the pathogenesis

Behcet's disease is a chronic inflammatory disorder of unknown etiology. It has long been postulated that immunological abnormalities, which are possi bly induced by, microbial pathogens in genetically susceptible individuals, are important in its pathogenesis. Recent findings have both supported the significance of genetic factors and better defined the nature of inflammat ion in Behcet's disease. Molecular genetic studies have strengthened the pr imary association of HLA-B51 with Behcet's disease. The exact pathogenic me chanism of the HLA-B51 molecule is still unknown, and its contribution to t he overall genetic susceptibility to Behcet's disease is estimated to be le ss than 20%. Spontaneous and/or induced overexpression of pro-inflammatory cytokines (mainly Th1 type)from various cellular sources seems responsible for the enhanced inflammatory reaction in Behcet's disease, and it may be a ssociated with the genetic susceptibility . An antigen-driven immune respon se superimposed on this primed-state and induced by heat shock proteins or other peptides,from different strains of streptoccocci or other microbial a gents has been suggested to trigger manifestations of Behcet's disease. End othelial activation/injury and the resultant occlusive vasculopathy may als o contribute to the tissue damage.