Osteonecrosis and bone infarction in association with Behcet's disease: Report of two cases

We describe two cases with Behcet's disease (BD) developing osteonecrosis o r bone infarction. One patient developed the extensive bone infarction of t he left knee without the use of corticosteroids. The other patient had oste onecrosis at the right femoral head. He had had a past history of significa nt corticosteroid administration to treat several complications of BD such as central nervous system involvement, uveitis, gastrointestinal involvemen t, and pulmonary involvement. Anticardiolipin (aCL) antibodies were positiv e in these two patients. One was IgG type, and the other was IgM type. Howe ver it remains unclear that there is relationship between the presence of a CL antibodies and occurrence of osteonecrosis.