Two-dimensional infrared spectroscopy: a promising new method for the timeresolution of structures

Recently, new methods for determining time-evolving structures using infrar ed analogs of NMR spectroscopy have been introduced that have outstanding p otential in structural biology. Already, within the past two years, structu res of dipeptides, tripeptides and pentapeptides have been determined on mu ch faster timescales than the conformational dynamics. Also, two-dimensiona l infrared correlation spectra of some proteins and isotopically edited ala nine-rich helices have been examined.