Role of heparan sulfate in fibroblast growth factor signalling: a structural view

Authors
Pellegrini, L
Citation
L. Pellegrini, Role of heparan sulfate in fibroblast growth factor signalling: a structural view, CURR OP STR, 11(5), 2001, pp. 629-634
Citations number
35
Categorie Soggetti
Biochemistry & Biophysics
Journal title
CURRENT OPINION IN STRUCTURAL BIOLOGY
ISSN journal
0959440X → ACNP
Volume
11
Issue
5
Year of publication
2001
Pages
629 - 634
Database
ISI
SICI code
0959-440X(200110)11:5<629:ROHSIF>2.0.ZU;2-S
Abstract
Fibroblast growth factors (FGFs) are among the best-studied heparin-binding proteins, and heparan sulfate proteoglycans regulate FGF signalling by dir ect molecular association with FGF and its tyrosine kinase receptor, FGFR. Two recently determined crystal structures of FGF-FGFR-heparin complexes ha ve provided new structural information on how heparin binds to FGF and FGFR , and lead to different models for receptor dimerisation.