Complement receptor 1 in autoimmune disorders

Complement receptor I (CRI) has gained much attention in recent years. The reason is manifold. Growing understanding on this protein has facilitated i nsight into the pathophysiology of autoimmune disorders. CRI, a polymorphic protein, is important as a complement regulatory protein, as well as a veh icle for immune complex clearance. Functional and clinical significance of CRI polymorphism, is a continuously revealing area in complement research. The levels of CRI are altered in autoimmune disorders like rheumatoid arthr itis, glomerulonephritis and systemic lupus erythematosus. This envisages C RI as a potential prognostic marker for such diseases. Lower levels of eryt hrocyte CRI are observed in patients suffering from the above diseases. Thi s partially explains the tissue injury and inflammatory manifestations in p atients suffering from these disorders. The benevolent role of CRI in autoi mmune and inflammatory disorders and propagation of disease manifestations due to its deficiency are further established with the therapeutic success of recombinant soluble CRI in inflammatory and autoimmune disorders. This r eview is a brief and update account of CRI and its importance in autoimmune disorders.