Disposition kinetics of danofloxacin and ciprofloxacin in broiler chickens

Disposition kinetics of danofloxacin and ciprofloxacin were studied in broi ler chickensfollowing intravenous, intramuscular and oral administration in a single dose of 5 and 10 mg/kg(-1) body weight respectively. In addition, tissue distribution and residual pattern of both drugs were determined. Th e maximum serum concentration (C-max) after intramuscular and oral administ ration were 1.03 and 0,55 mu /ml for danofloxacin and 2.92 and 1,24 mu /ml for ciprofloxacin attained at 0.8 and 2.43 and 0.55 and 1.27 hours for dano floxacin and ciprofloxacin respectively. The volume of distribution and sys temic bioavailability were higher for danofloxacin (Vd(ss) 2.21 L/kg and F % 96,56 and 81.4 %) as compared with ciprofloxacin (Vd(ss) 1.41 L/kg and F% 75.5 and 29.4 %). Data relating to intravenous injection for both drugs we re analyzed using a two compartment open model curve fit. Danofloxacin and ciprofloxacin were not detected in the serum of broilers at the 5(th) and 3 (rd) day respectively following the drugs withdrawal while were detected in liver, kidneys, spleen and lungs. Danofloxacin completely disappeared from all tissues at the 13(th), day after stopping of the drug medication but c iprofloxacin disappeared after 5 days only.