Short-term moderate weight loss and resistance training do not affect insulin-stimulated glucose disposal in postmenopausel women

OBJECTIVES - Moderate weight loss and exercise have been proposed as import ant tools treatment and prevention of type 2 diabetes. Therefore, we tested the hypothesis that short- term (4 weeks) moderate energy restriction (-75 0 kcal/clay) would result in a significant in- crease in insulin-stimulated glucose disposal (40 mU (.) m(-2) (.) min(-1) hyperinsulinemic- clamp) in moderately overweight postmenopausal women and that when combined with resi stance training (RT) an even greater effect would be seen. RESEARCH DESIGN AND METHODS - older women were randomly assigned to be a su bstantial health benefit for older energy restriction (WLoss groups n = 9) or energy restriction plus RT (RT + WLoss groups; n = 10). effective treatm ent for impaired glucose. RESULTS - For the WLoss versus the RT + WLoss groups, changes in body weigh t (- 3.0 +/- 2 kg vs. - 3.2 +/- 0.3 kg), fat mass (FM) (- 3.0 +/- 0.3 kg vs . - 3.2 +/- 0.3 kg), and percent body (BF) (-2.1 +/- 0.4 vs. -2.4 +/- 0.3%) were not different between groups. Muscle mass (group-by-time interaction, P = 0.04) was preserved in RT + WLoss (0.40 +/- 0.40 kg) and reduced in WL oss (-0.64 +/- 0.18 kg). There were no changes in fat-free mass (FFM) and r atio in either group. Whole body glucose disposal (WLoss 6.14 +/- 0.57 vs. 6.03 +/- 0.53, RT + WLoss 5.85 +/- 0.60 vs. 6.09 +/- 0.56 mg/kg of FFM/min) did not change in either group. weight loss, moderate short-term weight CONCLUSIONS - The results of this study demonstrate that short-term energy restriction resulting in moderate decreases in body weight (4.0 +/- 0.3%) a nd FM (8.2 +/- 0.7%) did not insulin-stimulated glucose disposal. The addit ion of RT to the hypoenergetic diet preserved muscle mass but provided no s ynergistic effect on insulin action. These results suggest that a greater c hange in body weight or FM may be necessary to observe a significant improv ement.