J. Zhang et al., Antioxidant supplementation prevents oxidation and inflammatory responses induced by sidestream cigarette smoke in old mice, ENVIR H PER, 109(10), 2001, pp. 1007-1009
Sidestream cigarette smoke (SSCS) makes up about 85% of significantly toxic
environmental tobacco smoke (ETS). Reactive oxygen species (ROS) in SSCS p
lay an important role in the pathogenesis of a wide range of diseases. Inte
rleukin-6 is a pro-inflammatory cytokine and is closely linked with patholo
gy in cardiovascular disease and conditions that have an inflammatory base.
Exposure to SSCS through a burning cigarette for 30 min/day, 5 days a week
, for 4 months increased interleukin-6 production in spleen and lipid perox
ide level in mouse liver. Our findings suggest that ROS induced by SSCS wil
l promote hepatic lipid peroxidation and may also contribute to an increase
in interleukin-6 cytokine production. Multiple antioxidants given as a die
tary supplement significantly normalized interieukin-6 cytokine production
and prevented hepatic lipid peroxidation. We conclude that the SSCS in mode
rate intake levels increased oxidation and promoted inflammatory cytokine i
nterleukin-6 production, whereas antioxidants prevented these changes.