COPPER-MEDIATED ALKYLATION OF VITAMIN-D C-RING - SYNTHESIS OF C-11-FUNCTIONALIZED 1-ALPHA,25-DIHYDROXYVITAMIN D-3

Authors
TORNEIRO M FALL Y CASTEDO L MOURINO A
Citation
M. Torneiro et al., COPPER-MEDIATED ALKYLATION OF VITAMIN-D C-RING - SYNTHESIS OF C-11-FUNCTIONALIZED 1-ALPHA,25-DIHYDROXYVITAMIN D-3, Tetrahedron, 53(31), 1997, pp. 10851-10870
Citations number
58
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
53
Issue
31
Year of publication
1997
Pages
10851 - 10870
Database
ISI
SICI code
0040-4020(1997)53:31<10851:CAOVC->2.0.ZU;2-6
Abstract
This work describes our studies on the functionalization at C11 of CD- ring fragments of vitamin D-3 using organocopper reagents. As an appli cation, an efficient, convergent synthesis of 11 alpha-[3,3-(dimethoxy )propyl] calcitriol analogue 2, which may be useful for the constructi on of affinity columns for the purification of 1 alpha,25-(OH)(2)-vita min D-3 receptors, is described. (C) 1997 Elsevier Science Ltd.