[H-1, N-15] NMR studies of the platination of phosphorothioate nucleotides- Monofunctional sulfur adducts versus macrochelation

Authors
Kratochwil, NA Parkinson, JA Sacht, C Murdoch, PD Brown, T Sadler, PJ
Citation
Na. Kratochwil et al., [H-1, N-15] NMR studies of the platination of phosphorothioate nucleotides- Monofunctional sulfur adducts versus macrochelation, EUR J INORG, (11), 2001, pp. 2743-2746
Citations number
19
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
ISSN journal
14341948 → ACNP
Issue
11
Year of publication
2001
Pages
2743 - 2746
Database
ISI
SICI code
1434-1948(200111):11<2743:[NNSOT>2.0.ZU;2-8
Abstract
cis-[PtI2((NH3)-N-15)(2)] reacts rapidly with guanosine-5'-O-(2-thiodiphosp hate) (GDP-beta -S) to form a macrochelate in which Pt bridges the phosphor othioate S and guanine N7 atoms, Phosphorothioate(alpha -S)-containing self -complementary decamer oligonucleotides give rise to relatively long lived S-bound monofunctional adducts, the fate of which is sequence dependent.