Factors stimulating bone formation

The aim of this review is to describe major approaches for stimulating bone healing and to review other factors affecting bone healing. Spinal bone fu sion after surgery is a demanding process requiring optimal conditions for clinical success. Bone formation and healing can be enhanced through variou s methods. Experimental studies have revealed an array of stimulative measu res. These include biochemical stimulation by use of hormones and growth fa ctors, physical stimulation through mechanical and electromagnetic measures , and bone grafting by use of bone tissue or bone substitutes. Newer biolog ical techniques such as stem cell transplantation and gene therapy can also be used to stimulate bone healing. Apart from bone transplantation, clinic al experience with the many stimulation modalities is limited. Possible are as for clinical use of these novel methods are discussed.