Prospective evaluation of Ki-67 labeling in predicting the recurrence and progression of superficial bladder transitional cell carcinoma

Citation
P. Blanchet et al., Prospective evaluation of Ki-67 labeling in predicting the recurrence and progression of superficial bladder transitional cell carcinoma, EUR UROL, 40(2), 2001, pp. 169-175
Citations number
10
Categorie Soggetti
Urology & Nephrology
Journal title
EUROPEAN UROLOGY
ISSN journal
03022838 → ACNP
Volume
40
Issue
2
Year of publication
2001
Pages
169 - 175
Database
ISI
SICI code
0302-2838(200108)40:2<169:PEOKLI>2.0.ZU;2-I
Abstract
Purpose:We studied a series of superficial transitional cell carcinoma of t he bladder to assess whether the Ki-67 labeleing index predicts recurrence and progression in a cohort of patients treated by transurethral resection alone or receiving adjuvant intravesical bacillus Calmette-Guerin therapy ( BCG). Materials and Methods: From 1989 to 1990, we prospectively studied 70 conse cutive cases of superficial transitional cell carcinoma of the bladder usin g Ki-67 immunostaining. The tumors were 43 pTa and 27 pT1. Thirteen were tr eated with transurethral resection only and 57 received adjuvant intravesic al BCG. The median follow-up times was 64 months. The threshold index value s of Ki-67 for recurrence and progression were determined using ROC curves. The relative predictive values of the Ki-67 labeling index and tumor chara cteristics for recurrence and progression were evaluated using Cox's propor tional hazards model. Results:A cutoff value of 13% was determined. The recurrence free survival rate at 5 years was 68% for cases with a Ki-67 labeling index of 13 or high er and 71% for those with an index of less than 13 (NS). The progression-fr ee survival rate at 5 years was 43% in cases with an index of 13 or higher and 89% in those with an index of less than 13 (p < 0.0001). Using multivar iate analsis the Ki-67 labeling index is an independent risk factor for tum or progression with a relative risk of 4.61 (p < 0.05). Conclusion: When BCG is used for high and intermediate risk superficial bla dder cancers, the Ki-67 labeling index is an independent predictive factor of progression but not of recurrence. Copyright (C) 2001 S. Karger AG, Base l.