Objective:The aim of this study was to evaluate the efficacy of topical app
lications of clobetasol propionate cream in the treatment of phimosis in bo
ys and a comparison of the results presented with an overview of the curren
t studies.
Methods: In a prospective study, 94 boys (mean age 5.5 years) were treated
with topical applications of 0.05% clobetasol propionate cream twice daily.
The prepuce was treated for 1 month, with an attempt at prepuce retraction
after 14 days. The boys were evaluated after 1 month of treatment and ever
y 3 months during follow-up.
Results: Of the 94 boys, 91 were available for follow-up, of whom 42 boys (
46.1%) achieved complete retraction of the prepuce, 24 (26.4%) had only pre
putial adhesions and 4 (4.4%) had partial retraction. Twenty-one boys (23.1
%) had no response. The treatment was continued in 13 boys with good result
s eventually. Seven boys (7.7%) had recurrence after a mean follow-up of 4.
3 months (range 2-7). No side effects were noted. Circumcision was necessar
y in 24 of the 91 boys (26.4%). The mean follow-up was 11.0 months (range 3
-18).
Conclusions: Local application of clobetasol propionate cream is a simple,
safe and effective treatment for phimosis in boys and avoids circumcision a
nd its associated risks. It should be offered first instead of circumcision
. Copyright (C) 2001 S. Karger AG, Basel.