Relationship between increased longevity and stress resistance as assessedthrough gerontogene mutations in Caenorhabditis elegans

Authors
Johnson, TE de Castro, E de Castro, SH Cypser, J Henderson, S Tedesco, P
Citation
Te. Johnson et al., Relationship between increased longevity and stress resistance as assessedthrough gerontogene mutations in Caenorhabditis elegans, EXP GERONT, 36(10), 2001, pp. 1609-1617
Citations number
30
Categorie Soggetti
Medical Research General Topics
Journal title
EXPERIMENTAL GERONTOLOGY
ISSN journal
05315565 → ACNP
Volume
36
Issue
10
Year of publication
2001
Pages
1609 - 1617
Database
ISI
SICI code
0531-5565(200111)36:10<1609:RBILAS>2.0.ZU;2-H
Abstract
We review the status of the hypothesis that interventions that increase the resistance to stress offer the potential for effective life prolongation a nd increased health. The work focuses on research in the nematode worm Caen orhabditis elegans and describes both published and unpublished results con sistent with this hypothesis. Correlations between stress resistance and lo ngevity among many gerontogene mutants is provided. (C) 2001 Elsevier Scien ce Inc. All rights reserved.