Nucleophilic substitution reactions of 4,5-dichloro-2-methyl-6-nitro-2H-pyridazin-3-one

Authors
Chang, KT Kim, JJ Kim, YK Park, HY Hyun, BH Shiro, M Yoon, YJ Lee, WS
Citation
Kt. Chang et al., Nucleophilic substitution reactions of 4,5-dichloro-2-methyl-6-nitro-2H-pyridazin-3-one, HETEROCYCLE, 55(10), 2001, pp. 1927
Citations number
6
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
55
Issue
10
Year of publication
2001
Database
ISI
SICI code
0385-5414(20011001)55:10<1927:NSRO4>2.0.ZU;2-Z
Abstract
4,5-Dichloro-2-methyl-6-nitro-2H-pyridazin-3-one (1) reacts with various su bstituted phenols and 2-mercaptopyrimidine in the presence of NaH or K2CO3 to give 3(2H)-pyridazinones (4, 5a-9a, 5b-9b, and 7e) in high yields. The r egiochemistry was confirmed by X-Ray analysis and nOe experiments.